MRI Striatal Volumes – A Biomarker for Clinical Trials in HD
Identifieur interne : 000527 ( Main/Exploration ); précédent : 000526; suivant : 000528MRI Striatal Volumes – A Biomarker for Clinical Trials in HD
Auteurs : Elizabeth H. AylwardSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Biological Markers.
- metabolism : Huntington Disease.
- methods : Clinical Trials as Topic.
- pathology : Corpus Striatum, Huntington Disease.
- therapy : Huntington Disease.
- Humans, Magnetic Resonance Imaging.
Abstract
There is an abundance of research showing that MRI striatal volumes decrease long before diagnosis of HD and closely track disease progression. Additional research indicates that these volumetric measures meet important criteria for a biomarker that can be used in clinical trials: They are (1) objectively measureable; (2) able to predict known endpoints; and (3) associated with known mechanisms of pathology of the disease. It is recommended that HD researchers consider formal application to regulatory agencies for biomarker status of volumetric MRI striatal measures, as it is anticipated that these measures can contribute significantly in the assessment of treatment effectiveness in HD.
Url:
DOI: 10.1002/mds.26013
PubMed: 25164586
PubMed Central: 4479278
Affiliations:
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Le document en format XML
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HD</title><author><name sortKey="Aylward, Elizabeth H" sort="Aylward, Elizabeth H" uniqKey="Aylward E" first="Elizabeth H." last="Aylward">Elizabeth H. Aylward</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological Markers (metabolism)</term><term>Clinical Trials as Topic (methods)</term><term>Corpus Striatum (pathology)</term><term>Humans</term><term>Huntington Disease (metabolism)</term><term>Huntington Disease (pathology)</term><term>Huntington Disease (therapy)</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biological Markers</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Clinical Trials as Topic</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Magnetic Resonance Imaging</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">There is an abundance of research showing that MRI striatal volumes
decrease long before diagnosis of HD and closely track disease progression.
Additional research indicates that these volumetric measures meet important
criteria for a biomarker that can be used in clinical trials: They are (1)
objectively measureable; (2) able to predict known endpoints; and (3) associated
with known mechanisms of pathology of the disease. It is recommended that HD
researchers consider formal application to regulatory agencies for biomarker
status of volumetric MRI striatal measures, as it is anticipated that these
measures can contribute significantly in the assessment of treatment
effectiveness in HD.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Aylward, Elizabeth H" sort="Aylward, Elizabeth H" uniqKey="Aylward E" first="Elizabeth H." last="Aylward">Elizabeth H. Aylward</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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